Recombinant Mouse FAM3D Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1981
Recombinant Mouse FAM3D Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1981
Catalog No.: BLPSN-1981
Product Overview
| Tag | Fc |
| Host Species | Mouse |
| Accession | NP_666162.1 |
| Synonym | FAM3D |
| Background | Family with sequence similarity 3 (FAM3) family is a novel cytokine-like gene family, which has four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy. |
| Description | A DNA sequence encoding the mouse FAM3D (NP_666162.1)(Met1-Met223) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Tyr 26 |
| AA Sequence | Met1-Met223 |
| Molecular Weight | The recombinant mouse FAM3D/Fc is a disulfide-linked homodimer. The reduced monomer comprises 439 a.a. and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 54 and 29 kDa in SDS-PAGE under reducing conditions. |
| Purity | (62.3+28.3)% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
