Recombinant Mouse Factor H Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1962
Recombinant Mouse Factor H Protein (His Tag)

Recombinant Mouse Factor H Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1962
Catalog No.: BLPSN-1962

Product Overview

Tag His
Host Species Mouse
Accession NP_034018.2
Synonym Mud-1, NOM, Sas-1, Sas1
Background Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.
Description A DNA sequence encoding the mouse Cfh (NP_034018.2) (Ser875-Val1252) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Ser 875
AA Sequence Ser875-Val1252
Molecular Weight The recombinant mouse Cfh consists 389 a.a. and predicts a molecular mass of 43.8 kDa.
Purity >90% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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