Recombinant Mouse EPCR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1790
Recombinant Mouse EPCR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1790
Catalog No.: BLPSN-1790
Product Overview
| Tag | Fc |
| Host Species | Mouse |
| Accession | Q64695 |
| Synonym | AI325044, Ccca, Ccd41, Epcr |
| Background | Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. |
| Description | A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was fused with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Leu 18 |
| AA Sequence | Met 1-Ser 214 |
| Molecular Weight | The secreted recombinant mouse PROCR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 438 a.a. and has a calculated molecular mass of 49.3 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 65-75 kDa in SDS-PAGE under reducing conditions. |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
