Recombinant Mouse DLL4 Protein

Beta LifeScience SKU/CAT #: BL-3771PS
Recombinant Mouse DLL4 Protein

Recombinant Mouse DLL4 Protein

Beta LifeScience SKU/CAT #: BL-3771PS
Catalog No.: BL-3771PS

Product Overview

Tag His
Host Species Mouse
Synonym Delta-like protein 4, Drosophila Delta homolog 4, Delta 4, Dll4.
Background Delta-Like4, also known as DLL4is implicated in the Notch signaling pathway as Notch ligand. Consequently DLL4negatively regulates endothelial cell proliferation, migration as well asangiogenic sprouting. DLL4 is vital for retinal progenitor proliferation andalso required for suppressing rod fates in late retinal progenitors and forproper generation of other retinal cell types. Furthermore, at some stage inthe spinal cord neurogenesis, DLL4 inhibits V2a interneuron fate.
Description DLL4 expressed in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (27-532 a.a.) and fused to a 6 a.a. His Tag at C-terminus containing a total of 512a.a. and having a molecular weight of 55.8kDa.DLL4 shows multiple bands between 50-70kDa on SDS-PAGE, reducing conditions and purified by unique purification methods.
Source Sf9
AA Sequence GSGIFQLRLQ EFVNQRGMLA NGQSCEPGCR TFFRICLKHF QATFSEGPCT FGNVSTPVLG TNSFVVRDKN SGSGRNPLQL PFNFTWPGTF SLNIQAWHTP GDDLRPETSP GNSLISQIII QGSLAVGKIW RTDEQNDTLT RLSYSYRVIC SDNYYGESCS RLCKKRDDHF GHYECQPDGS LSCLPGWTGK YCDQPICLSG CHEQNGYCSK PDECICRPGW QGRLCNECIP HNGCRHGTCS IPWQCACDEG WGGLFCDQDL NYCTHHSPCK NGSTCSNSGP KGYTCTCLPG YTGEHCELGL SKCASNPCRN GGSCKDQENS YHCLCPPGYY GQHCEHSTLT CADSPCFNGG SCRERNQGSS YACECPPNFT GSNCEKKVDR CTSNPCANGG QCQNRGPSRT CRCRPGFTGT HCELHISDCA RSPCAHGGTC HDLENGPVCT CPAGFSGRRC EVRITHDACA SGPCFNGATC YTGLSPNNFV CNCPYGFVGS RCEFPVGLPP SFPWVAHHHH HH
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation DLL4 protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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