Recombinant Mouse DKK3 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1622
Recombinant Mouse DKK3 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1622
Catalog No.: BLPSN-1622
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | NP_056629.1 |
| Synonym | AW061014, C87148 |
| Background | DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway. |
| Description | A DNA sequence encoding the extracellular domain (Met 1-Ile 349) of mouse DKK3 (NP_056629.1) precursor was expressed with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Pro 23 |
| AA Sequence | Met 1-Ile 349 |
| Molecular Weight | The secreted recombinant mouse DKK3 consists of 338 a.a. and has a calculated molecular mass of 38 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 65 kDa protein in SDS-PAGE under reducing conditions. |
| Purity | >97% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
