Recombinant Mouse Dectin-1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1590
Recombinant Mouse Dectin-1 Protein (His Tag)

Recombinant Mouse Dectin-1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1590
Catalog No.: BLPSN-1590

Product Overview

Tag His
Host Species Mouse
Accession NP_064392.2
Synonym beta-GR, BGR, Clecsf12
Background Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
Description A DNA sequence encoding the extracellular domain (Phe 69-Leu 244) of mouse CLEC7A (NP_064392.2) was fused with a His tag at the N-terminus.
Source HEK293
Predicted N Terminal His
AA Sequence Phe 69-Leu 244
Molecular Weight The secreted recombinant mouse CLEC7A consists of 193 a.a. and has a calculated molecular mass of 22.5 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 30-37 kDa in SDS-PAGE under reducing conditions.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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