Recombinant Mouse CBG Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0616
Recombinant Mouse CBG Protein (His Tag)

Recombinant Mouse CBG Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0616
Catalog No.: BLPSN-0616

Product Overview

Tag His
Host Species Mouse
Accession Q06770
Synonym AI265318, AV104445, Cbg
Background Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 9% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
Description A DNA sequence encoding the mouse SERPINA6 (Q06770) (Met 1-Ala 397) was fused with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Val 23
AA Sequence Met 1-Ala 397
Molecular Weight The secreted recombinant mouse SERPINA6 comprises 386 a.a. with a predicted molecular mass of 43.7 kDa. As a result of glycosylation, it migrates as an approximately 50-60 kDa band in SDS-PAGE under reducing conditions.
Purity >98% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recently viewed