Name: Recombinant Mouse CBG Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-0616
Availability: InStock

Catalog No.: BLPSN-0616

Product Overview

Tag	His
Host Species	Mouse
Accession	Q06770
Synonym	AI265318, AV104445, Cbg
Background	Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 9% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
Description	A DNA sequence encoding the mouse SERPINA6 (Q06770) (Met 1-Ala 397) was fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Val 23
AA Sequence	Met 1-Ala 397
Molecular Weight	The secreted recombinant mouse SERPINA6 comprises 386 a.a. with a predicted molecular mass of 43.7 kDa. As a result of glycosylation, it migrates as an approximately 50-60 kDa band in SDS-PAGE under reducing conditions.
Purity	>98% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.