Recombinant Mouse Biglycan / BGN Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-0404
Recombinant Mouse Biglycan / BGN Protein (Fc Tag)

Recombinant Mouse Biglycan / BGN Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-0404
Catalog No.: BLPSN-0404

Product Overview

Tag Fc
Host Species Mouse
Accession NP_031568.2
Synonym BG, DSPG1, PG-S1, PGI, SLRR1A
Background Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.
Description A DNA sequence encoding the mouse BGN (Met1-Lys369) was expressed with the Fc region of human IgG1 at the C-terminus.
Source HEK293
Predicted N Terminal Glu 20
AA Sequence Met1-Lys369
Molecular Weight The recombinant mouse BGN /Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 a.a. and has a predicted molecular mass of 66.5 KDa. The apparent molecular mass of the protein is approximately 67 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Purity >85% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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