Recombinant Mouse BAMBI Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0354
Recombinant Mouse BAMBI Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0354
Catalog No.: BLPSN-0354
Product Overview
| Tag | Fc |
| Host Species | Mouse |
| Accession | Q9D0L6 |
| Synonym | 2610003H06Rik |
| Background | BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis. |
| Description | A DNA sequence encoding the mouse BAMBI (Q9D0L6) (Met1-Ala152) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu 27 |
| AA Sequence | Met1-Ala152 |
| Molecular Weight | The recombinant mouse BAMBI /Fc is a disulfide-linked homodimer. The reduced monomer comprises 367 a.a. and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
