Recombinant Mouse ANTXR2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0227
Recombinant Mouse ANTXR2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0227
Catalog No.: BLPSN-0227
Product Overview
| Tag | His |
| Host Species | Mouse |
| Accession | NP_598499.1 |
| Synonym | 2310046B19Rik, AW561899, cI-35, CMG-2, CMG2 |
| Background | Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis. |
| Description | A DNA sequence encoding the extracellular domain of mouse ANTXR2 (NP_598499.1) (Met1-Gly318) was expressed with a C-terminal His tag. |
| Source | HEK293 |
| Predicted N Terminal | Gln 32 |
| AA Sequence | Met1-Gly318 |
| Molecular Weight | The recombinant mouse ANTXR2 comprises 298 a.a. and has a predicted molecular mass of 32.3 kDa. The apparent molecular mass of the protein is approximately 33.6 kDa in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
