Recombinant Mouse AGRP Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-0107
Recombinant Mouse AGRP Protein (Fc Tag)

Recombinant Mouse AGRP Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-0107
Catalog No.: BLPSN-0107

Product Overview

Tag Fc
Host Species Mouse
Accession NP_031453.1
Synonym Agrt, Art
Background Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
Description A DNA sequence encoding the mouse Agrp (NP_031453.1) (Ser82-Thr131) was expressed with the Fc region of human IgG1 at the N-terminus.
Source HEK293
Predicted N Terminal Glu
AA Sequence Ser82-Thr131
Molecular Weight The recombinant mouse Agrp consists 310 a.a. and predicts a molecular mass of 34.1 kDa.
Purity >80% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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