Recombinant Mouse AGRP Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0107
Recombinant Mouse AGRP Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0107
Catalog No.: BLPSN-0107
Product Overview
| Tag | Fc |
| Host Species | Mouse |
| Accession | NP_031453.1 |
| Synonym | Agrt, Art |
| Background | Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally. |
| Description | A DNA sequence encoding the mouse Agrp (NP_031453.1) (Ser82-Thr131) was expressed with the Fc region of human IgG1 at the N-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu |
| AA Sequence | Ser82-Thr131 |
| Molecular Weight | The recombinant mouse Agrp consists 310 a.a. and predicts a molecular mass of 34.1 kDa. |
| Purity | >80% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
