Recombinant Human WLS Protein

Beta LifeScience SKU/CAT #: BL-4360PS
Recombinant Human WLS Protein

Recombinant Human WLS Protein

Beta LifeScience SKU/CAT #: BL-4360PS
Catalog No.: BL-4360PS

Product Overview

Tag N/A
Host Species Human
Synonym C1orf139, EVI, GPR177, MRP, Protein wntless homolog, Integral membrane protein GPR177, Protein evenness interrupted homolog, Putative NF-kappa-B-activating protein 373, WLS.
Background WLS (Wnt trafficking regulator) is a multipass transmembrane protein which regulates the sorting and secretion of Wnt protein. WLS is necessitated for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. WLS is encoded by a gene which maps to human chromosome 1 and is expressed as multiple alternatively spliced isoforms. WLS promotes various cancers such as glioma tumourigenesis.
Description WLS Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 155a.a. (101-232a.a) and having a molecular weight of 17.8kDa. WLS is fused to a 23a.a. His-tag at N-terminus and purified by unique purification methods.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMEMSPWF QFMLFILQLD IAFKLNNQIR ENAEVSMDVS LAYRDDAFAE WTEMAHERVP RKLKCTFTSP KTPEHEGRYY ECDVLPFMEI GSVAHKFYLL NIRLPVNEKK KINVGIGEIK DIRLVGIHQN GGFTK.
Purity >90% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation WLS protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0),0.4M Urea and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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