Recombinant Human VWC2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4849
Recombinant Human VWC2 Protein (His Tag)

Recombinant Human VWC2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-4849
Catalog No.: BLPSN-4849

Product Overview

Tag His
Host Species Human
Accession NP_055747.1
Synonym PSST739, UNQ739
Background Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein which contains twoVWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.
Description A DNA sequence encoding the human VWC2 (NP_055747.1) (Met 1-Met 325) was expressed, fused with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Ser 28
AA Sequence Met 1-Met 325
Molecular Weight The recombinant human VWC2 consists of 309 a.a. and predictes a molecular mass of 34.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh VWC2 is approximately 45 kDa due to glycosylation.
Purity >95% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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