Name: Recombinant Human VSIG4 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4841
Availability: InStock

Recombinant Human VSIG4 Protein (His Tag)

Catalog No.: BLPSN-4841

Product Overview

Tag	His
Host Species	Human
Accession	Q9Y279
Synonym	CRIg, Z39IG
Background	VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type Ig domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, an V-type Ig domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type Ig domain of mouse VSIG4 shares 86% and 8% aa sequence identity with the V-type Ig domains of rat and human VSIG4, respectively.
Description	A DNA sequence encoding the human VSIG4 (Q9Y279-1) extracellular domain (Met 1-Pro 283) was expressed, fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Arg 20
AA Sequence	Met 1-Pro 283
Molecular Weight	The recombinant human VSIG4 consists of 275 a.a. and has a predicted molecular mass of 30.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhVSIG4 is approximately 45 kDa due to glycosylation.
Purity	>96% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.