Name: Recombinant Human VNN1 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-4831
Availability: InStock

Recombinant Human VNN1 Protein (His Tag)

Catalog No.: BLPSN-4831

Product Overview

Tag	His
Host Species	Human
Accession	NP_004657.2
Synonym	HDLCQ8, Tiff66
Background	Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.
Description	A DNA sequence encoding the human VNN1 (NP_004657.2) without the propeptide (Met 1-Ser 490) was expressed, fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Gln 22
AA Sequence	Met 1-Ser 490
Molecular Weight	The recombinant human VNN1 consists of 480 a.a. and has a predicted molecular mass of 53.7 kDa. It migrates as an approximately 70-75 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
Purity	>97% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.