Recombinant Human VDR Protein

Beta LifeScience SKU/CAT #: BL-4343PS
Recombinant Human VDR Protein

Recombinant Human VDR Protein

Beta LifeScience SKU/CAT #: BL-4343PS
Catalog No.: BL-4343PS

Product Overview

Tag Flag
Host Species Human
Synonym Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1.
Background Vitamin D receptors (VDRs) belong to the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors which form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney and has an imperative role in calcium homeostasis. VDRs inhibit expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3 and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Additionally, VDR has recently been recognized as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Hereditary mutations in the VDR gene leads to rickets, which is typified by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the VDR is localized to chromosome 12q12-q14.
Description Vitamin D Receptor Human Recombinant expressed in E.Coli is a full length protein consisting of 427a.a. having a molecular weight of 48.3kDa and fused with 5.5kDa amino-terminal His-Flag tag.VDR is purified by unique purification methods.
Source E.coli
AA Sequence MSYYHHHHHHDYDIPTTDYKDDDDKDYKDDDDKENLYFQGEFMEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS.
Purity >70.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation VDR protein is supplied in 50mM Tris, 150mM NaCl and 10% Glycerol, pH 7.5.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
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