Recombinant Human VAV1 Protein

Beta LifeScience SKU/CAT #: BL-4341PS
Recombinant Human VAV1 Protein

Recombinant Human VAV1 Protein

Beta LifeScience SKU/CAT #: BL-4341PS
Catalog No.: BL-4341PS

Product Overview

Tag N/A
Host Species Human
Synonym Vav 1 Guanine Nucleotide Exchange Factor, VAV, Vav 1Oncogene, Proto-Oncogene Vav.
Background Vav1 Guanine Nucleotide Exchange Factor (VAV1), belongs to the VAV gene family.The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases whichactivate pathways leading to actin cytoskeletal rearrangements and transcriptionalalterations. VAV1 is essential in hematopoiesis, taking part in T-cell andB-cell development and activation. VAV1 has been identified as the specificbinding partner of Nef proteins from HIV-1. In addition, VAV1 contains an SH2domain, which could show its function as a substrate for tyrosine kinases. Expressionof VAV1 is limited solely to cells of hematopoietic origin, as well as those ofthe erythroid, lymphoid and myeloid lineages. Among the diseases associatedwith VAV1 are cherubism, and hiv-1.
Description VAV1 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 400a.a. (189-565a.a) and having a molecular weight of 46.8kDa.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEIIFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQMKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQSLAHYGRPKI DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNKKWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK ECLGRVPPCG
Purity Greaterthan 85% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation VAV1 protein solution (0.25mg/ml) containing In 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30%glycerol and 2mM DTT.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
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