Name: Recombinant Human ULBP2 Protein
Brand: Beta LifeScience
SKU: BL-4892PS
Availability: InStock

Catalog No.: BL-4892PS

Product Overview

Tag	N/A
Host Species	Human
Synonym	ULBP2, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, UL16 BindingProtein 2, Retinoic Acid Early Transcript 1H, UL16-Binding Protein 2,ALCAN-Alpha, NKG2D Ligand 2, N2DL-2.
Background	ULBP2 is a member of the MHC class I family. ULBP2 is ligand for the NKG2D receptor, composed with at least ULBP1 and ULBP3. ULBPs promote multiple signaling pathways in primary NK cells, triggering the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D encourages calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, ULBP2 cooperates with soluble CMV glycoprotein UL16. This cooperation is blocked with the NKG2D receptor, providing a mechanism in which CMV infected cells can escape the immune system. Additionally, UL16 causes ULBP2 to be held in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Description	ULBP2 Human Recombinant expressed in Sf9 Baculovirus cellsis a single, glycosylated polypeptide chain containing 200a.a. (26-216a.a)and having a molecular weight of 22.7kDa (Molecular size on SDS-PAGE will appearat approximately 28-40kDa). ULBP2 is fused to a 9a.a. His-tag at C-terminusand purified by unique purification methods.
Source	Sf9
AA Sequence	ADPGRADPHSLCYDITVIPK FRPGPRWCAV QGQVDEKTFL HYDCGNKTVT PVSPLGKKLN VTTAWKAQNP VLREVVDILTEQLRDIQLEN YTPKEPLTLQ ARMSCEQKAE GHSSGSWQFS FDGQIFLLFD SEKRMWTTVH PGARKMKEKWENDKVVAMSF HYFSMGDCIG WLEDFLMGMD STLEPSAGAP LAMSHHHHHH.
Purity	>90% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	ULBP2 protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.