Recombinant Human UBQLN2 Protein
Beta LifeScience
SKU/CAT #: BL-4879PS
Recombinant Human UBQLN2 Protein
Beta LifeScience
SKU/CAT #: BL-4879PS
Collections: Other recombinant proteins, Recombinant proteins
Product Overview
| Tag | N/A |
| Host Species | Human |
| Synonym | UBQLN2,Ubiquilin 2, CHAP1, PLIC2, Protein Linking IAP With Cytoskeleton 2,Ubiquitin-Like Product Chap1/Dsk2, ALS15, N4BP4, NEDD4 Binding Protein 4,Nedd4 Binding Protein 4, DSK2 Homolog, Ubiquilin-2, HRIHFB2157, HPLIC-2,PLIC-2, DSK2. |
| Background | Ubiquilin-2, also known as UBQLN2 contains an N-terminal ubiquitin-likedomain and a C-terminal ubiquitin-associated domain. UBQLN2 is physicallylinked with proteasomes as well as ubiquitin ligases, and therefore isconsidered to functionally connect the ubiquitination machinery to theproteasome in order to affect in vivo protein degradation. Furthermore, UBQLN2binds the ATPase domain of the Hsp70-like Stch protein. Among the diseases whichare associated with UBQLN2: Amyotrophic lateral sclerosis 15, with or withoutfrontotemporal dementia as well as Amyotrophic lateral sclerosis type 15. |
| Description | UBQLN2 Human Recombinant expressed in E.Coli is a single,non-glycosylated polypeptide chain containing 647a.a. (1-624 a.a) andhaving a molecular weight of 68.1kDa. UBQLN2 is fused to a 23a.a. His-tagat N-terminus and purified by unique purification methods. |
| Source | E.coli |
| AA Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAENGES SGPPRPSRGPAAAQGSAAAP AEPKIIKVTV KTPKEKEEFA VPENSSVQQF KEAISKRFKS QTDQLVLIFA GKILKDQDTLIQHGIHDGLT VHLVIKSQNR PQGQSTQPSN AAGTNTTSAS TPRSNSTPIS TNSNPFGLGS LGGLAGLSSLGLSSTNFSEL QSQMQQQLMA SPEMMIQIME NPFVQSMLSN PDLMRQLIMA NPQMQQLIQR NPEISHLLNNPDIMRQTLEI ARNPAMMQEM MRNQDLALSN LESIPGGYNA LRRMYTDIQE PMLNAAQEQF GGNPFASVGSSSSSGEGTQP SRTENRDPLP NPWAPPPATQ SSATTSTTTS TGSGSGNSSS NATGNTVAAA NYVASIFSTPGMQSLLQQIT ENPQLIQNML SAPYMRSMMQ SLSQNPDLAA QMMLNSPLFT ANPQLQEQMR PQLPAFLQQMQNPDTLSAMS NPRAMQALMQ IQQGLQTLAT EAPGLIPSFT PGVGVGVLGT AIGPVGPVTP IGPIGPIVPFTPIGPIGPIG PTGPAAPPGS TGSGGPTGPT VSSAAPSETT SPTSESGPNQ QFIQQMVQAL AGANAPQLPNPEVRFQQQLE QLNAMGFLNR EANLQALIAT GGDINAAIER LLGSQPS. |
| Purity | Greaterthan 90.0% as determined by SDS-PAGE. |
| Endotoxin | <1.0 EU per μg by the LAL method. |
| Formulation | UBQLN2 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH7.4), 20% glycerol and 1mM DTT. |
| Stability | Recombinant protein is stable for 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
