Recombinant Human TYRP1 Protein

Beta LifeScience SKU/CAT #: BL-4325PS
Recombinant Human TYRP1 Protein

Recombinant Human TYRP1 Protein

Beta LifeScience SKU/CAT #: BL-4325PS
Catalog No.: BL-4325PS

Product Overview

Tag N/A
Host Species Human
Synonym Tyrosinase Related Protein 1, Tyrosinase-Related Protein1, Melanoma Antigen Gp75, Glycoprotein 75, DHICA Oxidase, Catalase B, CAS2, TRP1,TYRP, TRP, 5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase, EC 1.14.18.1, EC1.14.18.-, EC 1.14.18, B-PROTEIN, TRP-1, TYRRP, CATB, GP75, OCA3, 5,6-dihydroxyindole-2-carboxylicacid oxidase.
Background TYRP1,also known as 5, 6-dihydroxyindole-2-carboxylic acid oxidase, is a melanosomalenzyme which is a member of the tyrosinase family and takes a significant partin the melanin biosynthetic pathway. TYRP1 is a melanocyte-specificgene which is involved in eumelanin synthesis. Furthermore, TYRP1 is implicatedin the oxidation of 5,6-dihydroxyindole-2-carboxylicacid-DHICA into indole-5,6-quinone-2-carboxylic acid. TYRP1 is regulated by themicrophthalmia-associated transcriptionfactor-MITF.
Description TYRP1 Human Recombinant expressed in Sf9 Baculovirus cellsis a single, non-glycosylated polypeptide chain containing 462a.a. (25-477a.a)and having a molecular weight of 52.5kDa. (Molecular size on SDS-PAGE will appearat approximately 50-70kDa).TYRP1 is fused to a 6a.a. His-tag at C-terminusand purified by unique purification methods.
Source Sf9
AA Sequence ADLQFPRQCATVEALRSGMC CPDLSPVSGP GTDRCGSSSG RGRCEAVTAD SRPHSPQYPH DGRDDREVWP LRFFNRTCHCNGNFSGHNCG TCRPGWRGAA CDQRVLIVRR NLLDLSKEEK NHFVRALDMA KRTTHPLFVI ATRRSEEILGPDGNTPQFEN ISIYNYFVWT HYYSVKKTFLGVGQESFGEV DFSHEGPAFL TWHRYHLLRL EKDMQEMLQE PSFSLPYWNFATGKNVCDIC TDDLMGSRSN FDSTLISPNS VFSQWRVVCD SLEDYDTLGT LCNSTEDGPI RRNPAGNVARPMVQRLPEPQ DVAQCLEVGL FDTPPFYSNS TNSFRNTVEG YSDPTGKYDP AVRSLHNLAHLFLNGTGGQT HLSPNDPIFVLLHTFTDAVF DEWLRRYNAD ISTFPLENAP IGHNRQYNMV PFWPPVTNTE MFVTAPDNLG YTYEIQWPSR EFSVPEHHHHHH.
Purity >85.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation TYRP1 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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