Recombinant Human TRP2/DCT Protein
Beta LifeScience
SKU/CAT #: BLA-9266P
Recombinant Human TRP2/DCT Protein
Beta LifeScience
SKU/CAT #: BLA-9266P
Collections: Other recombinant proteins, Recombinant proteins
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Product Overview
Host Species | Human |
Accession | P40126 |
Synonym | L dopachrome tautomerase DCT Dopachrome delta isomerase Dopachrome tautomerase Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2 DT EC 5.3.3.12 L dopachrome Delta isomerase L-dopachrome Delta-isomerase L-dopachrome tautomerase TRP 2 TRP-2 TRP2 Tyrosinase related protein 2 Tyrosinase-related protein 2 TYRP2 TYRP2_HUMAN |
Description | Recombinant Human TRP2/DCT Protein was expressed in Wheat germ. It is a Protein fragment |
Source | Wheat germ |
AA Sequence | CTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCK FGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITT |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Liquid Solution |
Stability | The recombinant protein samples are stable for up to 12 months at -80°C |
Reconstitution | See related COA |
Unit Definition | For Research Use Only |
Storage Buffer | Shipped on dry ice. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle. |
Target Details
Target Function | Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). |
Subcellular Location | Melanosome membrane; Single-pass type I membrane protein. Melanosome. |
Protein Families | Tyrosinase family |
Database References |
Gene Functions References
- High DCT expression is associated with progressive multiple sclerosis. PMID: 28923927
- High DCT expression is associated with HPV16 Infection. PMID: 28095444
- Data indicate that the caveolin-1 (CAV1) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent. PMID: 27053106
- The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes. PMID: 25346513
- Report dopachrome tautomerase expression in mealanocytic tumors. PMID: 24709887
- The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease. PMID: 22898827
- Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells. PMID: 22988252
- human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway PMID: 20520707
- Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population. PMID: 20356546
- Data suggest that OTX2 may regulate retinal pigment epithelium (RPE)-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE. PMID: 12559959
- Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients. PMID: 15856458
- Transgenic Dct regulates neural progenitor cell proliferation in a mouse model. PMID: 16857183
- No genetic susceptibility or increased risk attributed to the tyrosinase gene family in Vogt-Koyanagi-Harada disease in Japanese. PMID: 17200659
- Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2. PMID: 17766092
- we studied a possible role of dopachrome tautomerase in the oxidative stress response in the amelanotic WM35 melanoma cell line. PMID: 18206123
- We observe strong evidence for positive selection for DCT in Asians PMID: 18312627
- Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo [TRP-2]. PMID: 18337837
- TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. PMID: 18674612
- tyrosinase-related protein 2 (TRP-2) transcript is not detected in the peripheral blood mononuclear cells (PBMC) of vitiligo patients PMID: 19284502
- Expression profiling demonstrated that the DCT-expressing cell population expressed adrenergic and muscarinic receptors and displayed transcriptional profiles distinct from dermal melanocytes PMID: 19855129