Recombinant Human TROP2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4673
Recombinant Human TROP2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-4673
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_002344.2 |
| Synonym | EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TACD2, TROP-2, TROP2 |
| Background | TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
| Description | A DNA sequence encoding the extracellular domain (Met 1-Thr 274) of human TROP2 (NP_002344.2) was expressed, fused with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | His 27 |
| AA Sequence | Met 1-Thr 274 |
| Molecular Weight | The recombinant human TROP2 comprises 259 a.a. and has a predicted molecular mass of 29.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh TROP2 is approximately 42-48 kDa due to glycosylation. |
| Purity | >96% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
