Recombinant Human TICAM2 Protein

Beta LifeScience SKU/CAT #: BL-4285PS
Recombinant Human TICAM2 Protein

Recombinant Human TICAM2 Protein

Beta LifeScience SKU/CAT #: BL-4285PS
Catalog No.: BL-4285PS

Product Overview

Tag N/A
Host Species Human
Synonym Toll-like receptor adaptor molecule 2, TIRP, TRAM, TICAM-2, Putative NF-kappa-B-activating protein 502, Toll-like receptor adaptor protein 3, TIRAP3, cytoplasmic adaptor, TIR domain-containing adapter molecule 2, toll/interleukin-1 receptor (TIR) domain-containing adapter protein, TRIF-related adaptor molecule.
Background TICAM2 belongs to the Toll/interleukin-1 receptor (TIR) family, a group of proteins which include the Toll-like receptors (TLRs). TICAM2, a cytoplasmic protein, physically bonds TLR4 and TICAM-1 and functionally transfers LPS-TLR4 signaling to TICAM-1, that sequentially activates IRF-3. TICAM2 takes part in IL1-triggered NF-kappa-B activation, operating upstream of IRAK1, IRAK2, TRAF6, and IKBKB.
Description TICAM2 Human Recombinant expressed in E.coli is a single, non-glycosylated polypeptide chain containing 259a.a. (1-235) and having a molecular weight of 29.4kDa.TICAM2 is fused to a 24a.a. His-tag at N-terminus and purified by unique purification methods.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSHMGIGKS KINSCPLSLS WGKRHSVDTS PGYHESDSKK SEDLSLCNVA EHSNTTEGPT GKQEGAQSVE EMFEEEAEEE VFLKFVILHA EDDTDEALRV QNLLQDDFGI KPGIIFAEMP CGRQHLQNLD DAVNGSAWTI LLLTENFLRD TWCNFQFYTS LMNSVNRQHK YNSVIPMRPL NNPLPRERTP FALQTINALE EESRGFPTQV ERIFQESVYK TQQTIWKETR NMVQRQFIA
Purity >85% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation The TICAM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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