Recombinant Human sRAGE Protein

Beta LifeScience SKU/CAT #: BL-4690PS
Recombinant Human sRAGE Protein

Recombinant Human sRAGE Protein

Beta LifeScience SKU/CAT #: BL-4690PS
Catalog No.: BL-4690PS

Product Overview

Tag Flag
Host Species Human
Synonym Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER, SRAGE, RAGE, MGC22357.
Background sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide.
Description sRAGE Human Recombinant expressed in HEK293cells is a single, glycosylated, polypeptide chain containing 331a.a. and having a molecular weight of 35.2 kDa. sRAGE Human is fused to Flag tag at C-Terminus.sRAGE Human is purified by unique purification methods.
Source HEK293
AA Sequence AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA AAADYKDDDDK.
Purity >95% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation The filtered (0.4µm) concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris and 50mM NaCl, pH 7.5.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.
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