Recombinant Human SOST Protein

Beta LifeScience SKU/CAT #: BL-4563PS
Recombinant Human SOST Protein

Recombinant Human SOST Protein

Beta LifeScience SKU/CAT #: BL-4563PS
Catalog No.: BL-4563PS

Product Overview

Tag His
Host Species Human
Synonym Sclerostin, SOST, CDD, VBCH.
Background Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin functions as a negative regulator of bone growth, by inhibiting bone formation. SOST is widely expressed at low levels, with highest levels in the bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. SOST gene defects cause sclerosteosis and bone dysplasia.
Description SOST Human Recombinant expressed in HEK293 cells is a single, glycosylated polypeptide chain (a.a 24-213) containing 196a.a. including a 6 a.a C-terminal His tag. The total molecular weight is 22.4kDa (calculated).
Source HEK293
AA Sequence QGWQAFKNDA TEIIPELGEY PEPPPELENN KTMNRAENGG RPPHHPFETK DVSEYSCREL HFTRYVTDGP CRSAKPVTEL VCSGQCGPAR LLPNAIGRGK WWRPSGPDFR CIPDRYRAQR VQLLCPGGEA PRARKVRLVA SCKCKRLTRF HNQSELKDFG TEAARPQKGR KPRPRARSAK ANQAELENAY HHHHHH.
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation SOST filtered (0.4 µm) and lyophilized from 0.5mg/ml in PBS and 5 % (w/v) trehalose, pH 7.4.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change afterone week at 4°C.
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