Recombinant Human SMAD1 Protein (GST Tag)

Beta LifeScience SKU/CAT #: BL-0254NP
Recombinant Human SMAD1 Protein (GST Tag)

Recombinant Human SMAD1 Protein (GST Tag)

Beta LifeScience SKU/CAT #: BL-0254NP
Catalog No.: BL-0254NP

Product Overview

Tag GST
Host Species Human
Accession Q15797
Synonym SMAD1 Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1;Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1;SMAD 1;Smad1;hSMAD1;MADR1
Background SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
Description Recombinant Human Mothers Against Decapentaplegic Homolog 1 is expressed by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.
Source E.coli
AA Sequence Met1-Ser465
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human SMAD1 Protein was lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 .
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human SMAD1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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