Recombinant Human SMAD1 Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BL-0254NP
Recombinant Human SMAD1 Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BL-0254NP
Catalog No.: BL-0254NP
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | Q15797 |
| Synonym | SMAD1 Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1;Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1;SMAD 1;Smad1;hSMAD1;MADR1 |
| Background | SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death. |
| Description | Recombinant Human Mothers Against Decapentaplegic Homolog 1 is expressed by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus. |
| Source | E.coli |
| AA Sequence | Met1-Ser465 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Human SMAD1 Protein was lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 . |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Human SMAD1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
