Recombinant Human SFTPD Protein

Beta LifeScience SKU/CAT #: BL-4191PS
Recombinant Human SFTPD Protein

Recombinant Human SFTPD Protein

Beta LifeScience SKU/CAT #: BL-4191PS
Catalog No.: BL-4191PS

Product Overview

Tag His
Host Species Human
Synonym Surfactant Protein D, Lung Surfactant Protein D, Collectin-7, COLEC7, SFTP4, PSP-D, SP-D, Surfactant-Associated Protein, Pulmonary 4, Surfactant, Pulmonary-Associated Protein D, Pulmonary Surfactant-Associated Protein D, Pulmonary Surfactant Apoprotein, PSPD.
Background Surfactant pulmonary-associated protein D (SFTPD) belongs to the collectin family of C-type lectins, which is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. SFTPD has humoral molecules of the innate immune system, and is deemed a functional candidate in chronic periodontitis. Moreover, SFTPD is involved in the development of acute and chronic inflammation of the lung. A number of human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. SFTPD contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. SFTPD interacts with complexes such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. In addition, SFTPD participates in the extracellular reorganization or turnover of pulmonary surfactant. SFTPD binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Description SFTPD expressed in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 363a.a. (22-375 a.a.) and having a molecular weight of 36.5kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).SFTPD is expressed with a 9a.a. His tag at C-Terminus and purified by unique purification methods.
Source Sf9
AA Sequence ADPEMKTYSH RTMPSACTLV MCSSVESGLPGRDGRDGREG PRGEKGDPGL PGAAGQAGMP GQAGPVGPKG DNGSVGEPGP KGDTGPSGPP GPPGVPGPAG REGPLGKQGN IGPQGKPGPK GEAGPKGEVG APGMQGSAGA RGLAGPKGER GVPGERGVPG NTGAAGSAGA GPQGSPGARGPPGLKGDKG IPGDKGAKGE SGLPDVASLR QQVEALQGQV QHLQAAFSQY KKVELFPNGQ SVGEKIFKTA GFVKPFTEAQ LLCTQAGGQL ASPRSAAENA ALQQLVVAKN EAAFLSMTDS KTEGKFTYPT GESLVYSNWA PGEPNDDGGS EDCVEIFTNG KWNDRACGEK RLVVCEFHHHHHH.
Purity >90.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation SFTPD protein solution (0.25mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4).
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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