Recombinant Human SEP15 Protein
Beta LifeScience
SKU/CAT #: BL-4586PS
Recombinant Human SEP15 Protein
Beta LifeScience
SKU/CAT #: BL-4586PS
Catalog No.: BL-4586PS
Product Overview
| Tag | N/A |
| Host Species | Human |
| Synonym | 15 KDa Selenoprotein, SEP15. |
| Background | 15 KDa Selenoprotein (SEP15) is aprotein-coding gene which contains a selenocysteine (Sec) residue at its activesite. The selenocysteineis encoded by the UGA codon that usually signals translation termination. The3' UTR of selenoproteingenes have a conventional stem-loop structure, the sec insertion sequence(SECIS), which is necessaryfor the recognition of UGA as a Sec codon rather than as a stop signal. Studiesin mouse propose that thisselenoprotein may have redox function and may be implicated in the qualitycontrol of protein folding. This gene is localized on chromosome 1p31, a genetic locus usuallymutated or deleted in human cancers.Diseases associated with SEP15 include lung cancer susceptibility, andchronic lymphocytic leukemia. |
| Description | SEP15 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 160a.a. (29-165 a.a) and having a molecular weight of 17.7kDa. |
| Source | E.coli |
| AA Sequence | MGSSHHHHHH SSGLVPRGSH MGSVSAFGAE FSSEACRELG FSSNLLCSSC DLLGQFNLLQ LDPDCRGCCQEEAQFETKKL YAGAILEVCG CKLGRFPQVQ AFVRSDKPKL FRGLQIKYVR GSDPVLKLLD DNGNIAEELSILKWNTDSVE EFLSEKLERI |
| Purity | >95.0% as determined by SDS-PAGE. |
| Endotoxin | <1.0 EU per μg by the LAL method. |
| Formulation | SEP15 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability | Recombinant protein is stable for 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
