Recombinant Human SEP15 Protein

Beta LifeScience SKU/CAT #: BL-4586PS
Recombinant Human SEP15 Protein

Recombinant Human SEP15 Protein

Beta LifeScience SKU/CAT #: BL-4586PS
Catalog No.: BL-4586PS

Product Overview

Tag N/A
Host Species Human
Synonym 15 KDa Selenoprotein, SEP15.
Background 15 KDa Selenoprotein (SEP15) is aprotein-coding gene which contains a selenocysteine (Sec) residue at its activesite. The selenocysteineis encoded by the UGA codon that usually signals translation termination. The3' UTR of selenoproteingenes have a conventional stem-loop structure, the sec insertion sequence(SECIS), which is necessaryfor the recognition of UGA as a Sec codon rather than as a stop signal. Studiesin mouse propose that thisselenoprotein may have redox function and may be implicated in the qualitycontrol of protein folding. This gene is localized on chromosome 1p31, a genetic locus usuallymutated or deleted in human cancers.Diseases associated with SEP15 include lung cancer susceptibility, andchronic lymphocytic leukemia.
Description SEP15 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 160a.a. (29-165 a.a) and having a molecular weight of 17.7kDa.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSVSAFGAE FSSEACRELG FSSNLLCSSC DLLGQFNLLQ LDPDCRGCCQEEAQFETKKL YAGAILEVCG CKLGRFPQVQ AFVRSDKPKL FRGLQIKYVR GSDPVLKLLD DNGNIAEELSILKWNTDSVE EFLSEKLERI
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation SEP15 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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