Recombinant Human RNF34 Protein

Beta LifeScience SKU/CAT #: BL-4550PS
Recombinant Human RNF34 Protein

Recombinant Human RNF34 Protein

Beta LifeScience SKU/CAT #: BL-4550PS
Catalog No.: BL-4550PS

Product Overview

Tag N/A
Host Species Human
Synonym Ring Finger Protein 34, E3 Ubiquitin Protein Ligase, RINGFinger Protein 34, Caspase Regulator CARP1, Caspases-8 And -10-Associated RINGFinger Protein 1, FYVE-RING Finger Protein Momo, Human RING Finger HomologousTo Inhibitor Of Apoptosis Protein, CARP-1, hRFI, RING Finger Protein RIFF, RFI,CARP1, RIF, RIFF, E3 Ubiquitin-Protein Ligase RNF34, EC 6.3.2.
Background RingFinger Protein 34 (RNF34) has E3 ubiquitin-protein ligase activity. RNF34 has aRINF finger, a motif recognized to be involved in protein-protein and protein-DNAinteractions. RNF34 regulates the levels of CASP8 and CASP10 by targeting themfor proteasomal degradation. In addition, RNF34 protects cells againstapoptosis induced by TNF. RNF34 also binds phosphatidylinositol 5-phosphateandphosphatidylinositol 3-phosphate. Alternatively splicing results in multipletranscript variants encoding distinct isoforms.
Description RNF34 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 396a.a. (1-373a.a) and having a molecular weight of 44.2kDa.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGS MRKAGAT SMWASCCGLL NEVMGTGAVR GQQSAFAGAT GPFRFTPNPEFSTYPPAATE GPNIVCKACG LSFSVFRKKH VCCDCKKDFC SVCSVLQENL RRCSTCHLLQ ETAFQRPQLMRLKVKDLRQY LILRNIPIDT CREKEDLVDL VLCHHGLGSE DDMDTSSLNS SRSQTSSFFT RSFFSNYTAPSATMSSFQGE LMDGDQTSRS GVPAQVQSEI TSANTEDDDD DDDEDDDDEE ENAEDRNPGL SKERVRASLSDLSSLDDVEG MSVRQLKEIL ARNFVNYSGC CEKWELVEKV NRLYKENEEN QKSYGERLQL QDEEDDSLCR ICMDAVIDCVLLECGHMVTC TKCGKRMSEC PICRQYVVRA VHVFKS
Purity Greaterthan 90.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation RNF34 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
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