Recombinant Human Rb Protein

Name: Recombinant Human Rb Protein
Brand: Beta LifeScience
SKU: BLA-7656P
Availability: InStock

Collections: Other recombinant proteins, Recombinant proteins

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Product Overview

Host Species	Human
Synonym	Exon 17 tumor GOS561 substitution mutation causes premature stop GOS563 exon 17 substitution mutation causes premature stop OSRC Osteosarcoma p105-Rb P105RB PP105 pp110 PPP1R130 pRb Prepro retinoblastoma associated protein Protein phosphatase 1 regulatory subunit 130 Rb RB transcriptional corepressor 1 RB_HUMAN RB1 RB1 gene Retinoblastoma 1 Retinoblastoma suspectibility protein Retinoblastoma-associated protein
Description	Recombinant Human Rb Protein was expressed in Baculovirus. It is a Full length protein
Source	Baculovirus
AA Sequence	TPRKTAATAA AAAAEPPAPP PPPPPEEDPE QDSGPEDLPL VRLEFEETEE PDFTALCQKL KIPDHVRERA WLTWEKVSSV DGVLGGYIQK KKELWGICIF IAAVDLDEMS FTFTELQKNI EISVHKFFNL LKEIDTSTKV DNAMSRLLKK YDVLFALFSK LERTCELIYL TQPSSSISTE INSALVLKVS WITFLLAKGE VLQMEDDLVI SFQLMLCVLD YFIKLSPPML LKEPYKTAVI PINGSPRTPR RGQNRSARIA KQLENDTRII EVLCKEHECN IDEVKNVYFK NFIPFMNSLG LVTSNGLPEV ENLSKRYEEI YLKNKDLDAR LFLDHDKTLQ TDSIDSFETQ RTPRKSNLDE EVNVIPPHTP VRTVMNTIQQ LMMILNSASD QPSENLISYF NNCTVNPKES ILKRVKDIGY IFKEKFAKAV GQGCVEIGSQ RYKLGVRLYY RVMESMLKSE EERLSIQNFS KLLNDNIFHM SLLACALEVV MATYSRSTSQ NLDSGTDLSF PWILNVLNLK AFDFYKVIES FIKAEGNLTR EMIKHLERCE HRIMESLAWL SDSPLFDLIK QSKDREGPTD HLESACPLNL PLQNNHTAAD MYLSPVRSPK KKGSTTRVNS TANAETQATS AFQTQKPLKS TSLSLFYKKV YRLAYLRLNT LCERLLSEHP ELEHIIWTLF QHTLQNEYEL MRDRHLDQIM MCSMYGICKV KNIDLKFKII VTAYKDLPHA VQETFKRVLI KEEEYDSIIV FYNSVFMQRL KTNILQYAST RPPTLSPIPH IPRSPYKFPS SPLRIPGGNI YISPLKSPYK ISEGLPTPTK MTPRSRILVS IGESFGTSEK FQKINQMVCN SDRVLKRSAE GSNPPKPLKK LRFDIEGSDE ADGSKHLPGE SKFQQKLAEM TSTRTRMQKQ KMNDSMDTSN KEEK
Molecular Weight	108 kDa
Purity	>95% SDS-PAGE.Purified by affinity and FPLC chromatography.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Liquid Solution
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped on dry ice. Upon delivery aliquot and store at -80°C. Avoid freeze / thaw cycle.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.