Recombinant Human RARRES2 Protein
Beta LifeScience
SKU/CAT #: BL-4507PS
Recombinant Human RARRES2 Protein
Beta LifeScience
SKU/CAT #: BL-4507PS
Catalog No.: BL-4507PS
Product Overview
| Tag | N/A |
| Host Species | Human |
| Synonym | Chemerin, TIG2, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433. |
| Background | RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. |
| Description | RARRES2 Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide chain containing 138a.a. and having a total molecular weight of 16 kDa. RARRES2 Human Recombinant is purified by unique purification methods. |
| Source | E.coli |
| AA Sequence | MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS. |
| Purity | >98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Endotoxin | <1.0 EU per μg by the LAL method. |
| Formulation | The RARRES2 protein was lyophilized from 0.02% TFA. |
| Stability | Recombinant protein is stable for 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Lyophilized Chemerin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Chemerin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
