Recombinant Human RARRES2 Protein

Beta LifeScience SKU/CAT #: BL-4507PS
Recombinant Human RARRES2 Protein

Recombinant Human RARRES2 Protein

Beta LifeScience SKU/CAT #: BL-4507PS
Catalog No.: BL-4507PS

Product Overview

Tag N/A
Host Species Human
Synonym Chemerin, TIG2, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
Background RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains.
Description RARRES2 Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide chain containing 138a.a. and having a total molecular weight of 16 kDa. RARRES2 Human Recombinant is purified by unique purification methods.
Source E.coli
AA Sequence MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.
Purity >98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation The RARRES2 protein was lyophilized from 0.02% TFA.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Lyophilized Chemerin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Chemerin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
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