Recombinant Human QKI Protein

Beta LifeScience SKU/CAT #: BL-4129PS
Recombinant Human QKI Protein

Recombinant Human QKI Protein

Beta LifeScience SKU/CAT #: BL-4129PS
Catalog No.: BL-4129PS

Product Overview

Tag N/A
Host Species Human
Synonym Hqk, hqkI, QK, QK1, QK3, Protein quaking, QuakingHomolog, KH Domain RNA Binding, RNA Binding Protein HQK, HKQ, KHDomain Containing, RNA Binding.
Background KH Domain RNA Binding also known as QKI is aRNA-binding protein which regulates pre-mRNA splicing, export of mRNAs from thenucleus, protein translation, and mRNA stability. QKIis involved in myelinizationand oligodendrocyte differentiation, and it may play a role in schizophrenia.Defects or deletions in the QKIare linked with astrocytic tumors and may be implicated in the pathogenesis ofschizophrenia. Among the diseases associated with QKI are6q terminal deletion syndrome, and schizophrenia.
Description QKI Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 364a.a. (1-341 a.a) and having a molecular weight of 40.1kDa.QKI is fused to a 23a.a. His-tag at N-terminus and purified by unique purification methods.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN.
Purity >85.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation QKI protein solution (0.25mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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