Recombinant Human PTPN4 Protein

Name: Recombinant Human PTPN4 Protein
Brand: Beta LifeScience
SKU: BL-1749PS
Availability: InStock

Collections: Other recombinant proteins, Recombinant proteins

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Product Overview

Tag	N/A
Host Species	Human
Synonym	Protein Tyrosine Phosphatase, Non-Receptor Type 4(Megakaryocyte), Protein-Tyrosine Phosphatase MEG1, PTPase-MEG1, EC 3.1.3.48,MEG, Tyrosine-Protein Phosphatase Non-Receptor Type 4, MegakaryocyteProtein-Tyrosine Phosphatase, Protein Tyrosine Phosphatase MEG1, MegakaryocytePhosphatase, PTPMEG1, PTPMEG, Tyrosine-protein phosphatase non-receptor type 4,Protein-tyrosine phosphatase MEG1.
Background	Protein Tyrosine Phosphatase Non Receptor Type-4, also known as PTPN4belongs to the protein tyrosine phosphatase, PTP family. PTPs are identified assignaling molecules which regulate a variety of cellular processes as well ascell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN4is broadly expressed non-receptor protein tyrosine phosphatase. In addition, PTPN4interacts with glutamate receptor delta 2 & epsilon, and affects glutamatereceptors signaling and/or in regulation of their activities through tyrosine dephosphorylation.
Description	PTPN4 Human Recombinant expressed in E.Coli is a single, non-glycosylatedpolypeptide chain containing 280a.a. (655-913 a.a) and having amolecular weight of 32kDa.PTPN4 is fused to a 21a.a. His-tag at N-terminusand purified by unique purification methods.
Source	E.coli
AA Sequence	MGSSHHHHHH SSGLVPRGSH MVLTQFDQLY RKKPGMTMSC AKLPQNISKN RYRDISPYDA TRVILKGNED YINANYINMEIPSSSIINQY IACQGPLPHT CTDFWQMTWE QGSSMVVMLT TQVERGRVKC HQYWPEPTGS SSYGCYQVTCHSEEGNTAYI FRKMTLFNQE KNESRPLTQI QYIAWPDHGV PDDSSDFLDF VCHVRNKRAG KEEPVVVHCSAGIGRTGVLI TMETAMCLIE CNQPVYPLDI VRTMRDQRAM MIQTPSQYRF VCEAILKVYE.
Purity	>85% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	PTPN4 protein solution (1mg/ml) containing 20mM Trisbuffer (pH 8.0) and 10% glycerol.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.