Recombinant Human PSMA7/HSPC Protein

Name: Recombinant Human PSMA7/HSPC Protein
Brand: Beta LifeScience
SKU: BLA-7422P
Availability: InStock

Collections: Car-nk targets proteins, Other recombinant proteins, Recombinant proteins

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Product Overview

Host Species	Human
Accession	O14818
Synonym	C6 HSPC MGC3755 OTTHUMP00000031449 OTTHUMP00000031450 OTTHUMP00000031453 Proteasome (prosome macropain) subunit alpha type 7 Proteasome alpha 7 subunit Proteasome subunit alpha 4 Proteasome subunit alpha type 7 Proteasome subunit alpha type-7 Proteasome subunit RC6 1 Proteasome subunit RC6-1 Proteasome subunit XAPC7 PSA7_HUMAN PSMA 7 PSMA7 RC6 1 XAPC7
Description	Recombinant Human PSMA7/HSPC Protein was expressed in E.coli. It is a Full length protein
Source	E.coli
AA Sequence	MGSSHHHHHH SSGLVPRGSH MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDIVVLGVEKKSV AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVEDPVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANAIGRGAKSVRE FLEKNYTDEA IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVAEIEKEKEENE KKKQKKAS
Molecular Weight	30 kDa including tags
Purity	>90% SDS-PAGE.Purified by using conventional chromatography techniques.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Formulation	Liquid Solution
Stability	The recombinant protein samples are stable for up to 12 months at -80°C
Reconstitution	See related COA
Unit Definition	For Research Use Only
Storage Buffer	Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycle.

Target Details

Target Function	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
Subcellular Location	Cytoplasm. Nucleus.
Protein Families	Peptidase T1A family
Database References	HGNC: 9536 OMIM: 606607 KEGG: hsa:5688 STRING: 9606.ENSP00000359910 UniGene: Hs.233952

Gene Functions References

salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with Inflammatory bowel disease. It can be a very promising biomarker PMID: 28523434
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes. PMID: 26624926
c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit PMID: 25620702
PSMA7 functions partially through downregulation NOD1. PMID: 23839082
PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro PMID: 22584585
High expression of PSMA7 was significantly correlated with liver metastasis. PMID: 19062718
The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. PMID: 16678104
PSMA7 may play an important role in colorectal cancer progression. PMID: 18202793
cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha degradation under hypoxic conditions. PMID: 19362550

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.