Recombinant Human PIK3IP1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3817
Recombinant Human PIK3IP1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3817
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | Fc |
Host Species | Human |
Accession | AAH11049.1 |
Synonym | HGFL, hHGFL(S) |
Background | PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, metabolism and survival in most cell types. Proper liver function and development highly depend on intact PI3K signal transduction. Aberrant PI3K pathway signaling in the liver is associated with hepatocellular carcinoma. PI3K signaling is involved in the homeostasis of lipid and glucose metabolism. Activation of the PI3K pathway induces lipogenesis and glycogenesis in the liver, since both Akt overexpressing transgenic mice and PTEN knockout mice develop fatty liver and hypoglycemia. PIK3IP1 overexpression can contribute to glucose homeostasis and fatty deposition. |
Description | A DNA sequence encoding the human PIK3IP1 (AAH11049.1) (Met1-Thr168) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Ser 22 |
AA Sequence | Met1-Thr168 |
Molecular Weight | The recombinant human PIK3IP1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 388 a.a. and has a predicted molecular mass of 42.7 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions. |
Purity | >85% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |