Recombinant Human PEA15 Protein

Beta LifeScience SKU/CAT #: BL-4090PS
Recombinant Human PEA15 Protein

Recombinant Human PEA15 Protein

Beta LifeScience SKU/CAT #: BL-4090PS
Catalog No.: BL-4090PS

Product Overview

Tag N/A
Host Species Human
Synonym Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED, PEA15, MAT1, HMAT1, MAT1H, PEA-15, HUMMAT1H.
Background PEA15 (Phospho-enriched protein in astrocytes 15kDa) is a death effector domain (DED)-containing protein mainly expressed in the central nervous system, principally in astrocytes. PEA15 is implicated in the regulation of various cellular processes including apoptosis, proliferation, glucose transport, adhesion and migration. Increased PEA15 levels have an affect tumorigenesis and cancer progression, therefore it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. PEA15 is ubiquitously expressed. PEA15 is most abundant in tissues such as the heart, brain, muscle and adipose tissue which use glucose as an energy source. Lower PEA15 expression is in glucose-producing tissues. Higher levels of PEA15 expression are found in tissues from individuals with type 2 diabetes than in controls.PEA15 expression is a significant prognostic marker in ovarian cancer.
Description PEA15 Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide chain containing 130a.a. (1-130 a.a.) and having a molecular weight of 15kDa.The PEA15 is purified by unique purification methods.
Source E.coli
AA Sequence MAEYGTLLQD LTNNITLEDL LKSACKED IPSEKSEEIT TGSAWFSFLE HNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA.
Purity >90.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation The PEA15 protein solution contains 20mM Tris-HCl buffer (pH 7.5), 1mM DTT and 10% Glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
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