Recombinant Human NDP Protein
Beta LifeScience
SKU/CAT #: BL-4018PS
Recombinant Human NDP Protein
Beta LifeScience
SKU/CAT #: BL-4018PS
Catalog No.: BL-4018PS
Product Overview
| Tag | N/A |
| Host Species | Human |
| Synonym | 800x600 Norrin, EVR2, FEVR, ND, Norrie disease protein, X-linkedexudative vitreoretinopathy 2 protein, NDP, Norrie Disease. Normal0falsefalsefalseEN-USX-NONEHE MicrosoftInternetExplorer4/* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";} |
| Background | Norrie Disease (NDP) is a secreted regulatory protein which activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP takes part in retinal vascularization by acting as a ligand for FZD4 which signals through stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP is involved in a pathway that regulates neural cell differentiation and proliferation and also in neuroectodermal cell-cell interaction. |
| Description | NDP Human Recombinant expressed in E.coli is a single, non-glycosylated polypeptide chain containing 132a.a. (25-133) and having a molecular weight of 14.8 kDa.NDP is fused to a 23a.a. His-tag at N-terminus and purified by unique purification methods. Normal0falsefalsefalseEN-USX-NONEHE MicrosoftInternetExplorer4/* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";} |
| Source | E.coli |
| AA Sequence | 800x600 MGSSHHHHHHSSGLVPRGSH MGSKTDSSFIMDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTSKLKALRLRCS GGMRLTATYR YILSCHCEEC NS. Normal 0 false false false EN-US X-NONE HE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";} |
| Purity | >80.0% as determined by SDS-PAGE. |
| Endotoxin | <1.0 EU per μg by the LAL method. |
| Formulation | 800x600 The NDP solution (0.5mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability | Recombinant protein is stable for 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
