Recombinant Human NDP Protein

Beta LifeScience SKU/CAT #: BL-4018PS
Recombinant Human NDP Protein

Recombinant Human NDP Protein

Beta LifeScience SKU/CAT #: BL-4018PS
Catalog No.: BL-4018PS

Product Overview

Tag N/A
Host Species Human
Synonym 800x600 Norrin, EVR2, FEVR, ND, Norrie disease protein, X-linkedexudative vitreoretinopathy 2 protein, NDP, Norrie Disease. Normal0falsefalsefalseEN-USX-NONEHE MicrosoftInternetExplorer4/* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";}
Background Norrie Disease (NDP) is a secreted regulatory protein which activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP takes part in retinal vascularization by acting as a ligand for FZD4 which signals through stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP is involved in a pathway that regulates neural cell differentiation and proliferation and also in neuroectodermal cell-cell interaction.
Description NDP Human Recombinant expressed in E.coli is a single, non-glycosylated polypeptide chain containing 132a.a. (25-133) and having a molecular weight of 14.8 kDa.NDP is fused to a 23a.a. His-tag at N-terminus and purified by unique purification methods. Normal0falsefalsefalseEN-USX-NONEHE MicrosoftInternetExplorer4/* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";}
Source E.coli
AA Sequence 800x600 MGSSHHHHHHSSGLVPRGSH MGSKTDSSFIMDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTSKLKALRLRCS GGMRLTATYR YILSCHCEEC NS. Normal 0 false false false EN-US X-NONE HE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable{mso-style-name:"Table Normal";mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:"";mso-padding-alt:0cm 5.4pt 0cm 5.4pt;mso-para-margin:0cm;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:"Calibri","sans-serif";}
Purity >80.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation 800x600 The NDP solution (0.5mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 0.4M Urea and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Recently viewed