Recombinant Human L Selectin Protein

Beta LifeScience SKU/CAT #: BL-4581PS
Recombinant Human L Selectin Protein

Recombinant Human L Selectin Protein

Beta LifeScience SKU/CAT #: BL-4581PS
Catalog No.: BL-4581PS

Product Overview

Tag N/A
Host Species Human
Synonym L-selectin, Lymph node homing receptor, Leukocyte adhesion molecule 1, LAM-1, Leukocyte surface antigen Leu-8, TQ1, gp90-MEL, Leukocyte-endothelial cell adhesion molecule 1, LECAM1, CD62 antigen-like family member L, CD62L antigen, LAM1, LNHR, LSEL, CD62L, LYAM1, Leu-8, PLNHR, hLHRc, Lyam-1, L-Sel.
Background L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin, which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells, which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
Description L-Selectin Human Recombinant is expressed in E. coli containing 294a.a. 39-332 fused to an amino terminal hexahistidine tag, having a total molecular weight of 37.55kDa.
Source E.coli
Purity >95% as determined by SDS-PAGE. Single band on Western Blot.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation L-Sel is supplied in 1x PBS and 50% Glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 1-2 weeks.Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles.
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