Recombinant Human Inhibin beta A Protein
Beta LifeScience
SKU/CAT #: BLPSN-2965
Recombinant Human Inhibin beta A Protein
Beta LifeScience
SKU/CAT #: BLPSN-2965
Catalog No.: BLPSN-2965
Product Overview
| Tag | N/A |
| Host Species | Human |
| Accession | NP_002183.1 |
| Synonym | EDF, FRP |
| Background | Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two beta subunits, betaA betaA (activin A), betaB betaB (activin B), or betaA betaB (activin AB). Inhibin is composed of an alpha and one of two beta subunits, betaA (inhibin A) or betaB (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. In addition, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects. |
| Description | A DNA sequence encoding mature form of human INHBA (NP_002183.1) (Gly311-Ser426) was expressed. The mature form sequences of the human, mouse, rat, cynomolgus and rhesus INHBA are identical. |
| Source | HEK293 |
| Predicted N Terminal | His |
| AA Sequence | Gly311-Ser426 |
| Molecular Weight | The recombinant human INHBA consists of 116 a.a. and predicts a molecular mass of 13 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 4-16ng/mL. |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
