Recombinant Human HSP70 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2466
Recombinant Human HSP70 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2466
Catalog No.: BLPSN-2466
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_005336.3 |
| Synonym | HEL-S-103, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1 |
| Background | HSPA1A is a member of the Hsp7 protein family. The 7 kilodalton heat shock proteins (Hsp7s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upon temperature shock or other stress stimuli, HSP are synthesized intracellularly, which may protect cells from protein denaturation or from death. Extracellularly, HSP can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates presentation of antigen peptide to T cells. Molecular chaperones of the Hsp7 family have diverse functions in cells. They assist the folding of newly synthesized and stress-denatured proteins, as well as the import of proteins into organelles, and the dissociation of aggregated proteins. The well-conserved Hsp7 chaperones are ATP dependent: binding and hydrolysis of ATP regulates their interactions with unfolded polypeptide substrates, and ATPase cycling is necessary for their function. All cellular functions of Hsp7 chaperones use the same mechanism of ATP-driven polypeptide binding and release. |
| Description | A DNA sequence encoding the human HSPA1A (NP_005336.3) (Ala2-Asp641) was expressed with a His tag at the N-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Met |
| AA Sequence | Ala2-Asp641 |
| Molecular Weight | The recombinant human HSPA1A consists of 651 a.a. and predicts a molecular mass of 71.4 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
