Recombinant Human HNRNPAB Protein

Name: Recombinant Human HNRNPAB Protein
Brand: Beta LifeScience
SKU: BL-3343PS
Availability: InStock

Collections: Other recombinant proteins, Recombinant proteins

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Product Overview

Tag	N/A
Host Species	Human
Synonym	Heterogeneous Nuclear Ribonucleoprotein A/B, ABBP-1, ABBP1,APOBEC1-Binding Protein 1, HnRNP A/B, Apobec-1 Binding Protein 1, ApolipoproteinB MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1, HnRNP TypeA/B Protein.
Background	Heterogeneous Nuclear Ribonucleoprotein A/B(HNRNPAB) is a member of the subfamily of ubiquitously expressed heterogeneousnuclear ribonucleoproteins(hnRNPs). The hnRNPs are expressed by RNA polymerase II and are components oftheheterogeneous nuclear RNA (hnRNA) complexes. They are linked with pre-mRNAsin the nucleus and seem to influence pre-mRNA processing and further aspects ofmRNA metabolism and transport. Whereas all of the hnRNPs are present in the nucleus, some seem toshuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinctnucleic acid binding properties. HNRNPAB, which binds to one of the componentsof the multiprotein editosomecomplex, has two repeats of quasi-RRM (RNA recognition motif) domains that bindto RNAs. Among the diseases associated with HNRNPABare wells syndrome, and cystic fibrosis.
Description	HNRNPAB Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 308a.a. (1-285 a.a) and having a molecular weight of 33kDa.
Source	E.coli
AA Sequence	MGSSHHHHHH SSGLVPRGSH MGSMSEAGEE QPMETTGATE NGHEAVPEGE SPAGAGTGAA AGAGGATAAP PSGNQNGAEGDQINASKNEE DAGKMFVGGL SWDTSKKDLK DYFTKFGEVV DCTIKMDPNT GRSRGFGFIL FKDAASVEKVLDQKEHRLDG RVIDPKKAMA MKKDPVKKIF VGGLNPEATE EKIREYFGEF GEIEAIELPM DPKLNKRRGF VFITFKEEEPVKKVLEKKFH TVSGSKCEIK VAQPKEVYQQ QQYGSGGRGN RNRGNRGSGG GGGGGGQGST NYGKSQRRGGHQNNYKPY
Purity	>95.0% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	HNRNPABprotein solution (0.25mg/ml) containing 30% glycerol and 1mM DTT.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.