Recombinant Human HMGN3 Protein

Beta LifeScience SKU/CAT #: BL-3331PS
Recombinant Human HMGN3 Protein

Recombinant Human HMGN3 Protein

Beta LifeScience SKU/CAT #: BL-3331PS
Catalog No.: BL-3331PS

Product Overview

Tag N/A
Host Species Human
Synonym High Mobility Group Nucleosomal Binding Domain 3, TRIP7,TR-Interacting Protein 7, High Mobility Group Nucleosome-BindingDomain-Containing Protein 3, Thyroid Hormone Receptor Interacting Protein 7, ThyroidReceptor-Interacting Protein 7, Thyroid Hormone Receptor Interactor 7, PNAS-24,PNAS-25, TRIP-7, High mobility group nucleosome-binding domain-containingprotein 3.
Background High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), binds thyroidhormone receptor beta, however it occurs only in the presence of thyroidhormone. Thyroid hormone receptors are hormone-dependent transcription factorswhich regulate expression of a variety of particular target genes. HMGN3 is considered to reduce the compactnessof the chromatin fiber in nucleosomes, in that way enhancing transcription fromchromatin templates.
Description HMGN3 Human Recombinant expressed in E.Coli is a single,non-glycosylated polypeptide chain containing 100a.a. (1-77 a.a) andhaving a molecular weight of 10.8 kDa.HMGN3 is fused to a 23a.a. His-tag at N-terminusand purified by unique purification methods.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTSAKKEPGAKIS RGAKGKKEEK QEAGKEGTEN.
Purity >95% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation HMGN3 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH7.0) and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks.
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