Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated

Beta LifeScience SKU/CAT #: BLPSN-2415
Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated

Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated

Beta LifeScience SKU/CAT #: BLPSN-2415
Catalog No.: BLPSN-2415

Product Overview

Tag His
Host Species Human
Accession NP_001973.2
Synonym ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK
Background Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4.
Description A DNA sequence encoding the extracellular domain (Met1-Thr643) of human ErbB3 (NP_001973.2) precursor was expressed with a C-terminal His tag. The purified protein was biotinylated in vitro.
Source HEK293
Predicted N Terminal Ser 20
AA Sequence Met1-Thr643
Molecular Weight The recombinant human ErbB3 protein consists of 635 amino and has a calculated molecular mass of 70.2 kDa.
Purity >95% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity 1.Measured by its binding ability in a functional ELISA.2.Immobilized biotinylated human ErbB3-His at 10ug/mL (100uL/well) can bind human Fc-NRG1(Cat:11609-H01H2), The EC50 of human Fc-NRG1 is 20- 60ng/mL.
Formulation Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated was lyophilized from sterile PBS,pH7.4.
Stability Recombinant Human HER3 / ERBB3 protein is stable up to 1 year at -70°C
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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