Name: Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated
Brand: Beta LifeScience
SKU: BLPSN-2415
Availability: InStock

Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated

Catalog No.: BLPSN-2415

Product Overview

Tag	His
Host Species	Human
Accession	NP_001973.2
Synonym	ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK
Background	Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4.
Description	A DNA sequence encoding the extracellular domain (Met1-Thr643) of human ErbB3 (NP_001973.2) precursor was expressed with a C-terminal His tag. The purified protein was biotinylated in vitro.
Source	HEK293
Predicted N Terminal	Ser 20
AA Sequence	Met1-Thr643
Molecular Weight	The recombinant human ErbB3 protein consists of 635 amino and has a calculated molecular mass of 70.2 kDa.
Purity	>95% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Bioactivity	1.Measured by its binding ability in a functional ELISA.2.Immobilized biotinylated human ErbB3-His at 10ug/mL (100uL/well) can bind human Fc-NRG1(Cat:11609-H01H2), The EC50 of human Fc-NRG1 is 20- 60ng/mL.
Formulation	Recombinant Human HER3 / ERBB3 Protein (His Tag), Biotinylated was lyophilized from sterile PBS,pH7.4.
Stability	Recombinant Human HER3 / ERBB3 protein is stable up to 1 year at -70°C
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.