Recombinant Human HER2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0069NP
Recombinant Human HER2 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0069NP
Catalog No.: BL-0069NP
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | P04626 |
| Synonym | HER2 Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu;Tyrosine kinase-type cell surface receptor HER2; ERBB2;MLN19;NGL;TKR1 |
| Background | Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| Description | Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is expressed by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Thr23-Thr652 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Recombinant Human HER2 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Human HER2 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
