Recombinant Human HER2 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0069NP
Recombinant Human HER2 Protein (Fc Tag)

Recombinant Human HER2 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0069NP
Catalog No.: BL-0069NP

Product Overview

Tag Fc
Host Species Human
Accession P04626
Synonym HER2 Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu;Tyrosine kinase-type cell surface receptor HER2; ERBB2;MLN19;NGL;TKR1
Background Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Description Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is expressed by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Thr23-Thr652
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human HER2 Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human HER2 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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