Recombinant Human GDF15 Protein (Mature Form, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2223
Recombinant Human GDF15 Protein (Mature Form, His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2223
Catalog No.: BLPSN-2223
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_004855.2 |
| Synonym | GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB |
| Background | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-beta superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| Description | A DNA sequence encoding the mature form of human GDF15 (NP_004855.2) (Ala197-Ile308) was expressed with a His tag at the N-terminus. |
| Source | Yeast |
| Predicted N Terminal | His |
| AA Sequence | Ala197-Ile308 |
| Molecular Weight | The recombinant mature form of human GDF15 consists of 130 a.a. and predicts a molecular mass of 14.2 kDa. |
| Purity | >90% as determined by SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 35 % CAN, 0.1 % TFA.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
