Recombinant Human GCSH Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2220

Recombinant Human GCSH Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2220
Catalog No.: BLPSN-2220
Product Overview
Tag | His |
Host Species | Human |
Accession | AAA36011.1 |
Synonym | GCE, NKH |
Background | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). GCSH is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in GCSH gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for GCSH gene. Also, several transcribed and non-transcribed pseudogenes of GCSH gene exist throughout the genome. |
Description | A DNA sequence encoding the mature form of human GCSH (AAA36011.1) (Ser49-Glu173) was expressed with a His tag at the N-terminus. |
Source | E.coli |
Predicted N Terminal | His |
AA Sequence | Ser49-Glu173 |
Molecular Weight | The recombinant human GCSH consists of 140 a.a. and predicts a molecular mass of 15.7 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions. |
Purity | >85% as determined by SDS-PAGE |
Endotoxin | Please contact us for more information. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |