Name: Recombinant Human GBP1 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-2208
Availability: InStock

Recombinant Human GBP1 Protein (His Tag)

Collections: Other recombinant proteins, Recombinant proteins

Product Overview

Tag	His
Host Species	Human
Accession	AAA35871.1
Synonym	GBP1
Background	Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1beta (IL-1beta), IL-1alpha, and tumor necrosis factor-alpha (TNF-alpha). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.
Description	A DNA sequence encoding the human GBP1 (AAA35871.1) (Met 1-Cys 589) was fused with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Met 1
AA Sequence	Met 1-Cys 589
Molecular Weight	The recombinant human GBP1 comprises 600 a.a. and has a predicted molecular mass of 69 kDa. rhGBP1 migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Purity	>95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.