Recombinant Human Frizzled 6 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2152
Recombinant Human Frizzled 6 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2152
Catalog No.: BLPSN-2152
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_003497.2 |
| Synonym | FZ-6, FZ6, HFZ6, NDNC10 |
| Background | FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis. |
| Description | A DNA sequence encoding the human FZD6 (NP_003497.2) (Met1-Val153) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | His 19 |
| AA Sequence | Met1-Val153 |
| Molecular Weight | The recombinant human FZD6 consists 369 a.a. and predicts a molecular mass of 42 kDa. |
| Purity | >90% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
