Name: Recombinant Human FKBP14 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-2096
Availability: InStock

Recombinant Human FKBP14 Protein (His Tag)

Catalog No.: BLPSN-2096

Product Overview

Tag	His
Host Species	Human
Accession	Q9NWM8
Synonym	EDSKMH, FKBP22, IPBP12
Background	FKBP14 belongs to the FK56-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.
Description	A DNA sequence encoding the human FKBP14 (Q9NWM8) (Met1-Lys207) was expressed with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Ala 20
AA Sequence	Met1-Lys207
Molecular Weight	The recombinant human FKBP14 consists of 199 a.a. and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 and 27 KDa band in SDS-PAGE under reducing conditions.
Purity	(73.1+25.2)% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.