Recombinant Human FKBP14 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2096
Recombinant Human FKBP14 Protein (His Tag)

Recombinant Human FKBP14 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2096
Catalog No.: BLPSN-2096

Product Overview

Tag His
Host Species Human
Accession Q9NWM8
Synonym EDSKMH, FKBP22, IPBP12
Background FKBP14 belongs to the FK56-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.
Description A DNA sequence encoding the human FKBP14 (Q9NWM8) (Met1-Lys207) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Ala 20
AA Sequence Met1-Lys207
Molecular Weight The recombinant human FKBP14 consists of 199 a.a. and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 and 27 KDa band in SDS-PAGE under reducing conditions.
Purity (73.1+25.2)% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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