Recombinant Human FKBP14 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2096

Recombinant Human FKBP14 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2096
Catalog No.: BLPSN-2096
Product Overview
Tag | His |
Host Species | Human |
Accession | Q9NWM8 |
Synonym | EDSKMH, FKBP22, IPBP12 |
Background | FKBP14 belongs to the FK56-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand. |
Description | A DNA sequence encoding the human FKBP14 (Q9NWM8) (Met1-Lys207) was expressed with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Ala 20 |
AA Sequence | Met1-Lys207 |
Molecular Weight | The recombinant human FKBP14 consists of 199 a.a. and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 and 27 KDa band in SDS-PAGE under reducing conditions. |
Purity | (73.1+25.2)% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |