Recombinant Human FGFR4 Protein (His&Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2078
Recombinant Human FGFR4 Protein (His&Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2078
Catalog No.: BLPSN-2078
Product Overview
| Tag | His&Fc |
| Host Species | Human |
| Accession | NP_002002.3 |
| Synonym | FGFR4, CD334, JTK2, TKF, fibroblast growth factor receptor 4 |
| Background | Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Rhabdomyosarcoma. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3. |
| Description | A DNA sequence encoding the extracellular domain (Met 1-Asp 369) of human FGFR4 (NP_002002.3) precursor was expressed with the C-terminal His tagged Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Leu 22 |
| AA Sequence | Met 1-Asp 369 |
| Molecular Weight | The recombinant human FGFR4/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 595 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh FGFR4/Fc monomer is approximately 100-110 kDa due to glycosylation. |
| Purity | >97% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c3T3 mouse fibroblasts. The ED50 for this effect is typically 10-60 ng/ml. |
| Formulation | Recombinant Human FGFR4 Protein (His&Fc Tag) was lyophilized from sterile PBS, pH 7.4 |
| Stability | Recombinant Human FGFR4 protein is stable up to 1 year at -70°C |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
